Differences in pathological substrate underlying dementia in African Americans
and Caucasians
 
   Lead Investigator:    Neill Graff-Radford
   Institution      :    Mayo Clinic
   E-Mail           :    graffradford.neill@mayo.edu
   Proposal ID      :    538


   Publications:


1  Graff-Radford NR,  Besser L , Crook JE,  Kukull W , Dickson DW
   African American Brain Autopsies from the National Alzheimer's Coordinating Center
   Abstract  Alzheimers Dement,12:P557-P558,2016,

   PUBLISHED



2  Graff-Radford NR,  Besser LM , Crook JE,  Kukull WA , Dickson DW
   Neuropathologic differences by race from the National Alzheimer's Coordinating Center
   Journal Article  Alzheimers Dement,12:669-677,2016,PMC4903907

   PUBLISHED





   Proposal Description:
   Compared to Caucasians African Americans have a higher prevalence of dementia, different genetic markers and higher risk factors of vascular disease such as diabetes and hypertension.  At this time we do not know what the pathological substrate underlying dementia in African Americans.  Our hypothesis is that the underlying pathology causing dementia in African Americans will differ from that in Caucasians. Specifically we expect there to be more vascular disease.  However we expect a substantial Alzheimer and Lewy Body disease contribution which may be similar to Caucasians.